Our understanding of the pathophysiological mechanisms of Alzheimer’s disease (AD) remains relatively unclear; however, the role of neuroinflammation as a key etiological feature is now widely accepted due to the consensus of epidemiological, neuroimaging, preclinical and genetic evidence. Consequently, non-steroidal anti-inflammatories (NSAIDs) have been investigated in epidemiological and clinical studies as potential disease modifying agents. […]

The risk of developing Alzheimer’s disease (AD) increases dramatically as we age. Similarly, the common malnutrition of zinc deficiency is also more prevalent in the elderly more due to changes in diet and zinc absorption as we age. We have shown that zinc deficiency induces the secretion of the inflammatory cytokine interleukin-1β (IL-1β) in macrophages […]